GEArray Q series Mouse Chemokines and Receptors Gene Array

Tel: 1.888.503.3187, 301.682.9200. Fax: 1.888.465.9859, 301.682.7300. Web:

www.superarray.com

Kit Size

MM-005-

02 / MM-005N-02

2 Arrays

MM-005-

04 / MM-005N-04

4 Arrays

MM-005-12 / MM-005N-12

12 Arrays

Description

Each GEArray Q series Mouse Chemokines and Receptors Gene Array contains 67 chemokine and chemokine receptor

genes. The regulation of chemokine and chemokine receptor expression plays fundamental roles in the development,

homeostasis, and function of immune system. It is also evident they function in other cell types, such as endothelial cells

and cells of the nervous system. Through a simple side-by-side hybridization, you can determine the expression profile of

these chemokine and their receptor genes by using your experimental RNA samples and the array and reagents provided

in the kit.

Functional Gene Grouping

Small Inducible Cytokines:

Subfamily A (Cys-Cys): Scya1 (TCA3), Scya2 (JE), Scya3 (MIP-1

α), Scya4 (MIP-1β), Scya5 (RANTES), Scya6 (C10),

Scya7 (MARC), Scya8 (MCP-2), Scya9 (MRP-2/ MIP-1r), Scya11 (eotaxin), Scya12 (mcp-5), Scya17 (TARC / ABCD-2),

Scya19 (MIP-3

β/ ELC), Scya20 (MIP-3α/ LARC), Scya21a (6Ckine/ SLC/ exodus-2), Scya22 (MDC / ABCD-1) Scya24

(CCL24 / MPIF-2 / eotaxin-2), Scya25 (TECK), Scya27 (ALP / mILC), Scya28 (MEC/CCL28)

Subfamily B (Cys-X-Cys): Cxcl16 (SR-PSOX), Gro1, Scyb2 (MIP2), Scyb5 (LIX/GCP-2/ENA78), Scyb9 (Mig), Scyb10 (IP-

10), Scyb11, Scyb13 (BLC / angie2), Scyb14 (Kec/Bmac /MIP-2g), Scyb15

Other Subfamily Members: Scyc1 (Lptn / lymphotactin), Scyd1 (fractalkine / neurotactin)

Chemokine Receptors: Blr1, Ccxcr1 (mXCR1), Cmkar3 (CXCR3), Cmkar4 (CXCR4), Cmkbr1 (CCR-1), Cmkbr1l1,

Cmkbr1l2, Cmkbr2, Cmkbr3, Cmkbr4, Cmkbr5, Cmkbr6 (CCR6), Cmkbr7 (EBI1), Cmkbr8 (CCR8), Cmkbr9 (GPR2),

Cmkbr10, Cmkor1, Cx3cr1, Cxcr6, D6-pending, IL8rb (Cmkar2), Ltb4r2, Pumag, Tapbp

Other Related Genes: Dfy, Emap2, Epo, Ifna11, Ifnab, Pf4, Ppbp, Human PRL homolog, Sdf1, Sdf2, Tcp10

References

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Sallusto F, Mackay CR, Lanzavecchia A (2000) The Role Of Chemokine Receptors In Primary, Effector, And Memeory Immune Responses.

Annu. Rev. Immunol 18: 593-620.

Rossi D, Zlotnik A (2000) The Biology of Chemokines And Their Receptors. Annu. Rev. Immunol 18: 217-242.

Zlotnik A, Yoshie O (2000) Chemokines: A New Classification System And Their Role In Immunity. Immunity 12: 121-127.

Krishna Vaddi, Margaret Keller, Robert C. Newton, editors. (1997) The Chemokine Facts Book Academic Press.

James J Campbell and Eugene C Butcher (2000) Chemokines In Tissue-Specific And Microenvironment-Specific Lymphocyte Homing. Current

Opinion in Immunology 12:336-341.